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After graduating from Yale, Dr. Cushing received his medical degree from Harvard Medical School in 1895 and taught at Johns Hopkins Hospital and Medial School before accepting appointment as Mosely Professor of Surgery at Harvard in 1912. His career at Harvard was interrupted by overseas service, during which he directed base hospitals in Europe during World War I.
Dr. Cushing returned to Yale in 1933, serving as Sterling Professor of Neurology in the School of Medicine and as Director of Studies in the History of Medicine from 1933 to 1937, and as Sterling Professor Emeritus until his death on October 7, 1939. He was married to Kate Crowell Cushing for more than thirty years. Mrs. Cushing took a great interest in her husband's students and hosted teas for them at the Medical School.
Dr. Cushing received many honors, including more than twenty honorary degrees, and was one of six individuals, and the only surgeon, to be elected to Honorary Fellowship in the British Royal College of Physicians. His biography of Sir William Osler was awarded the Pulitzer Prize in 1926.