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Yale Child Health Research Center (YCHRC)

Faculty

Dr. Clifford Bogue is Chief of the Section of Critical Care Medicine. His laboratory focuses on understanding mechanisms of heart and liver development. Dr. Bogue's studies are leading to insights as to how liver and heart formation occurs. These studies may provide new insights into cause of congenital heart and liver disease.

Dr. Peter Bowers is a member of the Section of Cardiology. His interest is the genetics of congential heart disease.

Dr. Michael Cappello is a member of the Infectious Diseases Section. Dr. Cappello's laboratory is trying to understand how parasitic infections impact maternal and child health. In addition, he has isolated novel proteins from parasites that may have potential use in the treatment of cardiovascular disorders and cancer.

Dr. Ramsay Fuleihan is a member of the Section of Immunology. Dr. Fuleihan is looking to learn how cells of the immune system develop from stem cells in the bone marrow and how a failure of this process leads to immune deficiency diseases that are characterized by a susceptibility to severe and recurrent infections. He has identified the genetic cause of the immune deficiency disease X-linked hyper IgM and is working to develop novel treatments for this disease.

Dr. Jeffrey Gruen is a member of the Section of Perinatology. Dr. Gruen has a research program aimed at discovering why dyslexia occurs. With this research, Dr. Gruen hopes to find causes and potential ways to diagnose reading disability, which affects a large proportion of American school children.

Dr. Margaret Hostetter, who is Chair of Pediatrics and Chief of the Section of Immunology, has a laboratory that focuses on two major areas. Dr. Hostetter's group has identified some mechanisms that contribute to the high risk of fungal infections in premature infants. She also is developing new and more effective vaccines that will prevent bacterial pneumonia.

Dr. Subramini Munirathinam, Ph.D. is a member of the Section of Developmental Endocrinology & Biology. His interests are in understanding mechanisms and brain injury in development.

Dr. George Porter is a member of the Section of Cardiology. His laboratory focuses on studying how the heart develops. These studies may provide new insights into cause of congenital heart disorders.

Dr. Scott Rivkees is a member of the Section of Developmental Endocrinology and Biology, and is the Director of the YCHRC. Dr. Rivkees' projects involve examining the development of the circadian system, which regulates sleep-wake cycles. Dr. Rivkees also is examining causes of brain injury in developing infants. Members of Dr. Rivkees laboratory are also looking at how the heart forms, which may lead to new insights into causes of congenital heart disease.

Dr. Christopher Wendler is a member of the Section of Developmental Endocrinology and Biology. His interests focus on heart development. Dr. Wendler's studies have identified factors that influence heart formation that may play a role in birth defects.

Dr. Satish Ghatpande is a member of the Section of Developmental Endocrinology and Biology. His interests focus on heart development. Dr. Ghatpande is looking at the role that retinoids play in heart formation.

Dr. Ping-xia Zhang is a member of the Section of Immunology. Her interest is in gene therapy of primary immune deficiency diseases and lymphocyte development. She is examining the role of the homeobox gene Hhex in B cell development and she is developing a model for gene therapy of X-linked hyper IgM.